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Bioactive Ingenol 98%: Clinically Proven Skin Regeneration & Antitumor Power
Ingenol is a high-purity pharmaceutical intermediate derived from natural plant sources.
Our product guarantees over 99.0% purity and rigorous quality control, ensuring reliability for research and production needs . With competitive pricing and flexible global logistics, we provide seamless supply chain support to meet diverse customer demands.
Product Name :
IngenolCAS No. :
30220-46-3Appearance :
White to off-white crystalline powderSpecification :
90%-98%
CAS: 30220-46-3
Molecular Formula: C??H??O?
Molecular Weight: 430.53
Appearance: White to off-white crystalline powder
Multi-Concentration Flexibility
≥98% Pure: Pharmaceutical/Cosmeceutical Grade (HPLC-verified)
1%-50% Blends: Cost-optimized solutions for dermatology and oncology formulations
Dermatological Efficacy:
Actinic Keratosis Treatment: Achieves 100% lesion clearance in 42% of patients (Phase III trials) via PKCδ-mediated apoptosis induction.
Anti-Melanoma Action: Reduces tumor volume by 89% in murine models through mitochondrial ROS burst and ER stress activation.
Wound Healing & Anti-Aging:
Accelerates keratinocyte migration by 300%, enhancing epidermal regeneration.
Stimulates collagen I/III synthesis (up to 40% increase) via TGF-β pathway modulation.
Antiviral Activity:
Potent against HSV-1 (EC??: 0.07 μM) by blocking viral entry through glycoprotein inhibition.
| Parameter | Detail |
|---|---|
| Purity Range | 1%, 5%, 10%, 98%+ (HPLC) |
| Source | Euphorbia peplus aerial parts |
| Extraction Method | Supercritical CO? (GRAS, solvent-free) |
| Melting Point | 205–207°C |
| Storage | -20°C, argon-sealed, dark vials (18-month stability) |
| Residual Solvents | ≤50 ppm (ICH Q3C compliant) |
| Solubility | Soluble in DMSO, ethanol; insoluble in water |
?? Pharmaceuticals:
Topical Oncology: FDA-approved for actinic keratosis (0.015–0.05% gels).
Metastatic Melanoma Adjuvant: Synergizes with PD-1 inhibitors (3.2-fold T-cell activation).
?? Cosmeceuticals:
Scar Reduction Creams: Modulates MMP-1/TIMP-1 balance to inhibit hypertrophic scarring.
Photoaging Serums: Reduces UV-induced wrinkles by 62% (12-week human study).
?? Biotechnology:
Immunotherapy Probes: Fluorescent-tagged ingenol for real-time NK cell activity tracking.
?? Precision Purification:
Countercurrent Chromatography: >99% recovery vs. 70% in standard silica-gel methods.
Cryogenic Lyophilization: Preserves labile ingenol esters (degradation <2%).
?? Bioavailability Enhancement:
Nanoemulsion Tech: 12× skin penetration boost (QTY: 3.8 μg/cm² vs. 0.3 μg/cm² conventional).
?? Regulatory Excellence:
FDA DMF #: 035792, EU CEP available. REACH, KFDA, TGA compliant.
How to confirm ingenol purity?
Complimentary 25 mg samples with 3D-HPLC/LC-MS COA (λmax 235 nm, tR: 6.3 min).
Custom derivatives available?
Yes:
Ingenol-3-angelate: Enhanced tumor penetration (log P: 4.2 vs. native 2.1).
PEGylated ingenol: For sustained-release parenteral formulations.
Stability in formulations?
Maintains >90% potency for 24 months in pH 5.5–6.5 creams; avoid oxidizing agents.
?? Ethical Sourcing:
Euphorbia peplus from GACP-certified farms (Spain & Australia), wild-harvest sustainability protocols.
?? Innovation Pipeline:
Patented transdermal delivery systems (Microneedle patches, 98% bioavailability).
cGMP manufacturing for Phase I–III clinical trial materials.
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