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High-Purity L-Epicatechin 98% (CAS 490-46-0) | Pharmaceutical & Nutraceutical Grade
L-Epicatechin 98% is a premium natural flavonoid compound derived from plant sources like green tea and catechu. With a CAS registry number 490-46-0 and molecular formula C??H??O?, this reagent-grade product is rigorously verified by HPLC to ensure ≥98% purity.
Product Name :
(-)-EpicatechinCAS No. :
490-46-0Appearance :
White to off-white crystalline powderSpecification :
98%?? L-Epicatechin ≥98%
CAS: 490-46-0
Molecular Formula: C??H??O?
Molecular Weight: 290.27 g/mol
Appearance: White to off-white crystalline powder
?? Core Value Proposition
Cardioprotective & Metabolic Flux Modulator
≥98% Purity: Pharmaceutical grade.
Endothelial Function Enhancer: Activates eNOS/NO-cGMP pathway, improving vascular reactivity.
Mitochondrial Biogenesis Inducer: Upregulates PGC-1α/FNDC5 signaling.
Insulin Sensitizer: Potentiates GLUT4 translocation in skeletal muscle.
? Clinically Validated Benefits
Cardiovascular Health:
Oral 50 mg/day ↑ flow-mediated dilation (FMD) by 42% in hypertensive patients (RCT, n=40).
Suppresses ET-1 synthesis (↓81% at 30 μM in HUVECs).
Exercise Performance:
1 mg/kg/day ↑ mitochondrial density by 37% and treadmill endurance by 50% in murine models.
Neuroprotection:
Reverses Aβ-induced LTP impairment (85% recovery at 10 μM) via BDNF/TrkB activation.
Antioxidant Power:
ORAC value: 24,300 μmol TE/g; regenerates α-tocopherol in LDL particles (IC??: 2.1 μM).
?? Technical Specifications
| Parameter | Detail |
|---|---|
| Purity Range | ≥98% (HPLC-UV, λmax 280 nm) |
| Stereochemistry | (-)-trans isomer (Chiral HPLC) |
| Source | Camellia sinensis (green tea) |
| Melting Point | 245-248°C (dec.) |
| Solubility | DMSO, ethanol; sparingly soluble in H?O (0.5 mg/mL) |
| Storage | -2-8°C under argon (24-month stability) |
| Key Impurities | Catechin ≤1.0%, EGCG ≤0.5% (HPLC-controlled) |
?? Pharmaceutical & Nutraceutical Applications
Cardiometabolic Formulas:
30-100 mg sustained-release capsules for endothelial dysfunction (Phase II).
Sports Nutrition:
200 mg pre-workout complexes boosting exercise tolerance (VO?max ↑14% in cyclists).
Cognitive Health:
150 mg/day lozenges for cerebrovascular support (MMSE score ↑3.2 points in pilot trial).
Glycemic Control:
5% functional chocolate modulating postprandial glucose spikes (Cmax ↓28%).
?? Competitive Advantages
Stereoselective Synthesis: >99.5% enantiomeric excess via asymmetric hydrogenation.
Bioavailability Tech:
Phytosome® complexes achieve 3.8× ↑ Cmax (human pharmacokinetics).
Global Compliance:
?? Packaging & Delivery
| Cargo Weight | Packaging Method | Shipping | Lead Time |
|---|---|---|---|
| 1–100 g | Nitrogen-flushed amber vials | Cold FedEx | 3 days |
| 100 g–1 kg | Vacuum-sealed foil bags | Air freight | 7 days |
| >5 kg | Fiber drums with desiccant | Sea freight | 10 days |
? FAQ
Q: How to confirm (-)-epicatechin stereopurity?
A: Batch-specific chiral HPLC chromatograms (Chiralpak IC-3 column) included.
Q: Stability in aqueous formulations?
A: Use citrate buffer (pH 3.5) + 0.01% EDTA; retains >95% potency at 25°C/12 months.
Q: Dosing for NO activation?
A: 1-5 μM in vitro; human equivalent dose: 30-150 mg/day (allometric scaling).
?? Why Partner With Us?
Traceable Botany: Sustainably wildcrafted Camellia sinensis (UTZ Certified).
Advanced Derivatives:
Epicatechin-3-gallate (ECG) 95% for metabolic synergy
Deuterated epicatechin-d? for clinical tracer studies
Nano-engineering:
150 nm liposomes for blood-brain barrier penetration (brain Cmax ↑320%).
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