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Pure Quillaic Acid (CAS 631-01-6) | HPLC≥98%/NMR Validated | Bulk Sourcing
Quillaic Acid (synonyms: Quillaja sapogenin,皂皮酸) is a natural triterpenoid aglycone derived from the bark of the Chilean tree Quillaja saponaria Mol. It is primarily used in scientific research for its dose-dependent analgesic activity and serves as a reference standard in phytochemical studies.
Product Name :
Quillaic AcidCAS No. :
631-01-6Appearance :
Fine White PowderSpecification :
98%
| Parameter | Specification |
|---|---|
| IUPAC Name | (3β,4α,16α)-3,16-Dihydroxy-23-oxoolean-12-en-28-oic acid |
| Molecular Formula | C??H??O? |
| Molecular Weight | 486.68 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 294°C |
| Boiling Point | 613.3±55.0°C (at 760 mmHg) |
| Density | 1.2±0.1 g/cm³ |
| Optical Rotation | [α]²?D +56.1° (c=2.9 in pyridine) |
| Solubility | Soluble: DMSO (88 mg/mL), methanol, ethanol, acetone Insoluble: Water |
| Storage | 2–8°C (dry, airtight, light-resistant container; stability >2 years) |
Analgesic Effects:
Exhibits dose-dependent pain relief in preclinical models.
Phytochemical Reference:
Used as a high-purity standard (≥98%) for quality control in herbal extracts and saponin analysis.
Research Applications:
Pharmacology: Mechanistic studies on triterpenoid bioactivity.
Natural Product Chemistry: Isolation and structural validation of saponins.
| Quantity | Packaging | Purity | |
|---|---|---|---|
| 20 mg | Sealed glass vial + desiccant | ≥98% | |
| 50 mg | Amber HDPE bottle + vacuum seal | ≥98% | |
| 1 g | Pharma-grade HDPE drum + desiccant | ≥98% | |
| Notes: |
Purity validated by HPLC-DAD/ELSD, NMR, and MS.
Custom packaging (e.g., β-cyclodextrin complexes) available for solubility enhancement.
Toxicity:
Acute oral LD?? (rat) >1,000 mg/kg; non-genotoxic (OECD 471 compliant).
Hazards:
Skin/Irritant: Causes skin and eye damage; use PPE (gloves, goggles).
Inhalation Risk: Avoid dust formation6.
Regulatory Compliance:
EINECS: 211-149-8; heavy metals controlled (As <0.1 ppm, Pb <0.2 ppm; ICP-MS).
Solubility Optimization:
For cell-based assays: Dissolve in DMSO (up to 180.8 mM), then dilute in buffer.
Analytical Methods:
HPLC Conditions: C18 column, gradient MeCN/H?O + 0.1% formic acid, detection at 210 nm.
Structural Confirmation: ¹H/¹³C NMR (CDCl? or pyridine-d?).
Stability:
Stable for >24 months at 2–8°C; degrades in alkaline conditions (pH >7).
Green Extraction: Supercritical technology (yield ≥96%, solvent-free).
Batch Consistency: Rigorous QC via HPLC/MS/NMR ensures reproducibility.
Multi-Format Flexibility: Suitable for oral, topical, and injectable formulations (via solubility modifiers).
Summary: Quillaic acid (CAS 631-01-6) is a high-value triterpenoid for analgesic research and phytochemical standardization. Its validated purity (≥98%), safety profile, and scalable supply make it ideal for academic and industrial R&D. For batch-specific COA or custom formulations, contact suppliers directly. ??
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